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The Secretary may: Direct agency priorities Encourage enforcement discretion Appoint or replace FDA leadership Order internal review of regulatory positions Support re-evaluation of prior safety determinations The Secretary may not: Bypass statutory requirements Ignore the Administrative Procedure Act Unilaterally legalize peptide compounding Regulatory change must follow defined legal pathways

Sep 2016;4(5):800-7

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Reading and Interpreting COA Documentation A research-grade BPC-157 COA should include an HPLC chromatogram with a clearly visible main peak and a numeric purity percentage (target 99%)